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Damaged and senescent cells in our tissues and organs are constantly replaced by new ones, derived from the activation of stem cells – undifferentiated multipotent cells known for their ability to self-renew and differentiate into various functional cell types....
Advancing age is accompanied by a progressive declineofthe immune system called immunosenescence- anevolutionary processaffecting immune and vaccine responses (dysimmunity) and, consequently,the incidence of pathologies (e.g., infections, autoimmune reactions, chronic...
Apart from replicativesenescence due to telomere shortening at each mitosis, senescence can be induced prematurely by stresses, such as oxidative, metabolic, genotoxic or oncogenic stresses. In contrast to quiescence – a reversible cell cycle arrest – senescence is...
Aging is accompanied by tissue degeneration. Cellular senescence is at the origin of many degenerative processes. All cells can be affected, but certain tissues/organs are more sensitive, starting with the cardiovascular system, which is the first to be affected....