Stem Cell Renewal : Anti-Aging Perspectives

Stem Cell Renewal : Anti-Aging Perspectives

Damaged and senescent cells in our tissues and organs are constantly replaced by new ones, derived from the activation of stem cells – undifferentiated multipotent cells known for their ability to self-renew and differentiate into various functional cell types....
Senolysis and cancer : Therapeutic perspectives

Senolysis and cancer : Therapeutic perspectives

Apart from replicativesenescence due to telomere shortening at each mitosis, senescence can be induced prematurely by stresses, such as oxidative, metabolic, genotoxic or oncogenic stresses. In contrast to quiescence – a reversible cell cycle arrest – senescence is...
Senotherapeutic agents: Advances and perspectives

Senotherapeutic agents: Advances and perspectives

Aging is accompanied by tissue degeneration. Cellular senescence is at the origin of many degenerative processes. All cells can be affected, but certain tissues/organs are more sensitive, starting with the cardiovascular system, which is the first to be affected....