Les cellules endommagées et sénescentes de nos tissus et organes sont constamment remplacées par de nouvelles, issues de l’activation de cellules souches – des cellules indifférenciées multipotentes connues pour leurs capacités d’auto-renouvellement et de...
L’avancée en âge s’accompagne d’un déclin progressif du système immunitaire appelé immunosénescence – un processus évolutif affectant les réponses immunes et vaccinales (dysimmunité) et, par voie de conséquence, l’incidence de pathologies (e.g., infections,...
Indépendamment de la sénescence réplicative due au raccourcissement des télomères à chaque mitose, la sénescence peut être induite prématurément par des stress, tels que des stress oxydants, métaboliques, génotoxiques ou encore oncogéniques. Contrairement à...
Le vieillissement s’accompagne de dégénérescences tissulaires. La sénescence cellulaire est à l’origine de nombreux processus dégénératifs. Toutes les cellules peuvent être touchées, mais certains tissus/organes s’avèrent plus sensibles, à commencer par le...
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